Information complexity and applications

I have previously here on the blog posted multiple lectures in my ‘lecture-posts’, or I have combined a lecture with other stuff (e.g. links such as those in the previous ‘random stuff’ post). I think such approaches have made me less likely to post lectures on the blog (if I don’t post a lecture soon after I’ve watched it, my experience tells me that I not infrequently simply never get around to posting it), and combined with this issue is also the issue that I don’t really watch a lot of lectures these days. For these reasons I have decided to start posting single lecture posts here on the blog; when I start thinking about the time expenditure of people reading along here in a way this approach actually also seems justified – although it might take me as much time/work to watch and cover, say, 4 lectures as it would take me to read and cover 100 pages of a textbook, the time expenditure required by a reader of the blog would be very different in those two cases (you’ll usually be able to read a post that took me multiple hours to write in a short amount of time, whereas ‘the time advantage’ of the reader is close to negligible (maybe not completely; search costs are not completely irrelevant) in the case of lectures). By posting multiple lectures in the same post I probably decrease the expected value of the time readers spend watching the content I upload, which seems suboptimal.

Here’s the youtube description of the lecture, which was posted a few days ago on the IAS youtube account:

“Over the past two decades, information theory has reemerged within computational complexity theory as a mathematical tool for obtaining unconditional lower bounds in a number of models, including streaming algorithms, data structures, and communication complexity. Many of these applications can be systematized and extended via the study of information complexity – which treats information revealed or transmitted as the resource to be conserved. In this overview talk we will discuss the two-party information complexity and its properties – and the interactive analogues of classical source coding theorems. We will then discuss applications to exact communication complexity bounds, hardness amplification, and quantum communication complexity.”

He actually decided to skip the quantum communication complexity stuff because of the time constraint. I should note that the lecture was ‘easy enough’ for me to follow most of it, so it is not really that difficult, at least not if you know some basic information theory.

A few links to related stuff (you can take these links as indications of what sort of stuff the lecture is about/discusses, if you’re on the fence about whether or not to watch it):
Computational complexity theory.
Shannon entropy.
Shannon’s source coding theorem.
Communication complexity.
Communications protocol.
Information-based complexity.
Hash function.
From Information to Exact Communication (in the lecture he discusses some aspects covered in this paper).
Unique games conjecture (Two-prover proof systems).
A Counterexample to Strong Parallel Repetition (another paper mentioned/briefly discussed during the lecture).
Pinsker’s inequality.

An interesting aspect I once again noted during this lecture is the sort of loose linkage you sometimes observe between the topics of game theory/microeconomics and computer science. Of course the link is made explicit a few minutes later in the talk when he discusses the unique games conjecture to which I link above, but it’s perhaps worth noting that the link is on display even before that point is reached. Around 38 minutes into the lecture he mentions that one of the relevant proofs ‘involves such things as Lagrange multipliers and optimization’. I was far from surprised, as from a certain point of view the problem he discusses at that point is conceptually very similar to some problems encountered in auction theory, where Lagrange multipliers and optimization problems are frequently encountered… If you are too unfamiliar with that field to realize how the similar problem might appear in an auction theory context, what you have there are instead auction partipants who prefer not to reveal their true willingness to pay; and some auction designs actually work in a very similar manner as does the (pseudo-)protocol described in the lecture, and are thus used to reveal it (for some subset of participants at least)).

March 12, 2017 Posted by | Computer science, Game theory, Lectures, Papers | Leave a comment

Random Stuff

i. On the youtube channel of the Institute for Advanced Studies there has been a lot of activity over the last week or two (far more than 100 new lectures have been uploaded, and it seems new uploads are still being added at this point), and I’ve been watching a few of the recently uploaded astrophysics lectures. They’re quite technical, but you can watch them and follow enough of the content to have an enjoyable time despite not understanding everything:

This is a good lecture, very interesting. One major point made early on: “the take-away message is that the most common planet in the galaxy, at least at shorter periods, are planets for which there is no analogue in the solar system. The most common kind of planet in the galaxy is a planet with a radius of two Earth radii.” Another big take-away message is that small planets seem to be quite common (as noted in the conclusions, “16% of Sun-like stars have an Earth-sized planet”).

Of the lectures included in this post this was the one I liked the least; there are too many (‘obstructive’) questions/interactions between lecturer and attendants along the way, and the interactions/questions are difficult to hear/understand. If you consider watching both this lecture and the lecture below, I would say that it would probably be wise to watch the lecture below this one before you watch this one; I concluded that in retrospect some of the observations made early on in the lecture below would have been useful to know about before watching this lecture. (The first half of the lecture below was incidentally to me somewhat easier to follow than was the second half, but especially the first half hour of it is really quite good, despite the bad start (which one can always blame on Microsoft…)).

ii. Words I’ve encountered recently (…or ‘recently’ – it’s been a while since I last posted one of these lists): Divagationsperiphrasis, reedy, architravesettpedipalp, tout, togs, edentulous, moue, tatty, tearaway, prorogue, piscine, fillip, sop, panniers, auxology, roister, prepossessing, cantle, catamite, couth, ordure, biddy, recrudescence, parvenu, scupper, husting, hackle, expatiate, affray, tatterdemalion, eructation, coppice, dekko, scull, fulmination, pollarding, grotty, secateurs, bumf (I must admit that I like this word – it seems fitting, somehow, to use that word for this concept…), durophagy, randy, (brief note to self: Advise people having children who ask me about suggestions for how to name them against using this name (or variants such as Randi), it does not seem like a great idea), effete, apricity, sororal, bint, coition, abaft, eaves, gadabout, lugubriously, retroussé, landlubber, deliquescence, antimacassar, inanition.

iii. “The point of rigour is not to destroy all intuition; instead, it should be used to destroy bad intuition while clarifying and elevating good intuition. It is only with a combination of both rigorous formalism and good intuition that one can tackle complex mathematical problems; one needs the former to correctly deal with the fine details, and the latter to correctly deal with the big picture. Without one or the other, you will spend a lot of time blundering around in the dark (which can be instructive, but is highly inefficient). So once you are fully comfortable with rigorous mathematical thinking, you should revisit your intuitions on the subject and use your new thinking skills to test and refine these intuitions rather than discard them. One way to do this is to ask yourself dumb questions; another is to relearn your field.” (Terry Tao, There’s more to mathematics than rigour and proofs)

iv. A century of trends in adult human height. A figure from the paper (Figure 3 – Change in adult height between the 1896 and 1996 birth cohorts):


(Click to view full size. WordPress seems to have changed the way you add images to a blog post – if this one is even so annoyingly large, I apologize, I have tried to minimize it while still retaining detail, but the original file is huge). An observation from the paper:

“Men were taller than women in every country, on average by ~11 cm in the 1896 birth cohort and ~12 cm in the 1996 birth cohort […]. In the 1896 birth cohort, the male-female height gap in countries where average height was low was slightly larger than in taller nations. In other words, at the turn of the 20th century, men seem to have had a relative advantage over women in undernourished compared to better-nourished populations.”

I haven’t studied the paper in any detail but intend to do so at a later point in time.

v. I found this paper, on Exercise and Glucose Metabolism in Persons with Diabetes Mellitus, interesting in part because I’ve been very surprised a few times by offhand online statements made by diabetic athletes, who had observed that their blood glucose really didn’t drop all that fast during exercise. Rapid and annoyingly large drops in blood glucose during exercise have been a really consistent feature of my own life with diabetes during adulthood. It seems that there may be big inter-individual differences in terms of the effects of exercise on glucose in diabetics. From the paper:

“Typically, prolonged moderate-intensity aerobic exercise (i.e., 30–70% of one’s VO2max) causes a reduction in glucose concentrations because of a failure in circulating insulin levels to decrease at the onset of exercise.12 During this type of physical activity, glucose utilization may be as high as 1.5 g/min in adolescents with type 1 diabetes13 and exceed 2.0 g/min in adults with type 1 diabetes,14 an amount that quickly lowers circulating glucose levels. Persons with type 1 diabetes have large interindividual differences in blood glucose responses to exercise, although some intraindividual reproducibility exists.15 The wide ranging glycemic responses among individuals appears to be related to differences in pre-exercise blood glucose concentrations, the level of circulating counterregulatory hormones and the type/duration of the activity.2

August 13, 2016 Posted by | Astronomy, Demographics, Diabetes, language, Lectures, Mathematics, Physics, Random stuff | Leave a comment

Random stuff

I find it difficult to find the motivation to finish the half-finished drafts I have lying around, so this will have to do. Some random stuff below.


(15.000 views… In some sense that seems really ‘unfair’ to me, but on the other hand I doubt neither Beethoven nor Gilels care; they’re both long dead, after all…)

ii. New/newish words I’ve encountered in books, on or elsewhere:

Agleyperipeteia, disseverhalidom, replevinsocage, organdie, pouffe, dyarchy, tauricide, temerarious, acharnement, cadger, gravamen, aspersion, marronage, adumbrate, succotash, deuteragonist, declivity, marquetry, machicolation, recusal.

iii. A lecture:

It’s been a long time since I watched it so I don’t have anything intelligent to say about it now, but I figured it might be of interest to one or two of the people who still subscribe to the blog despite the infrequent updates.

iv. A few wikipedia articles (I won’t comment much on the contents or quote extensively from the articles the way I’ve done in previous wikipedia posts – the links shall have to suffice for now):

Duverger’s law.

Far side of the moon.

Preference falsification.

Russian political jokes. Some of those made me laugh (e.g. this one: “A judge walks out of his chambers laughing his head off. A colleague approaches him and asks why he is laughing. “I just heard the funniest joke in the world!” “Well, go ahead, tell me!” says the other judge. “I can’t – I just gave someone ten years for it!”).

Political mutilation in Byzantine culture.

v. World War 2, if you think of it as a movie, has a highly unrealistic and implausible plot, according to this amusing post by Scott Alexander. Having recently read a rather long book about these topics, one aspect I’d have added had I written the piece myself would be that an additional factor making the setting seem even more implausible is how so many presumably quite smart people were so – what at least in retrospect seems – unbelievably stupid when it came to Hitler’s ideas and intentions before the war. Going back to Churchill’s own life I’d also add that if you were to make a movie about Churchill’s life during the war, which you could probably relatively easily do if you were to just base it upon his own copious and widely shared notes, then it could probably be made into a quite decent movie. His own comments, remarks, and observations certainly made for a great book.

May 15, 2016 Posted by | Astronomy, Computer science, History, language, Lectures, Mathematics, Music, Random stuff, Russia, Wikipedia | Leave a comment

Random Stuff

i. Some new words I’ve encountered (not all of them are from, but many of them are):

Uxoricide, persnickety, logy, philoprogenitive, impassive, hagiography, gunwale, flounce, vivify, pelage, irredentism, pertinacity,callipygous, valetudinarian, recrudesce, adjuration, epistolary, dandle, picaresque, humdinger, newel, lightsome, lunette, inflect, misoneism, cormorant, immanence, parvenu, sconce, acquisitiveness, lingual, Macaronic, divot, mettlesome, logomachy, raffish, marginalia, omnifarious, tatter, licit.

ii. A lecture:

I got annoyed a few times by the fact that you can’t tell where he’s pointing when he’s talking about the slides, which makes the lecture harder to follow than it ought to be, but it’s still an interesting lecture.

iii. Facts about Dihydrogen Monoxide. Includes coverage of important neglected topics such as ‘What is the link between Dihydrogen Monoxide and school violence?’ After reading the article, I am frankly outraged that this stuff’s still legal!

iv. Some wikipedia links of interest:


Steganography […] is the practice of concealing a file, message, image, or video within another file, message, image, or video. The word steganography combines the Greek words steganos (στεγανός), meaning “covered, concealed, or protected”, and graphein (γράφειν) meaning “writing”. […] Generally, the hidden messages appear to be (or be part of) something else: images, articles, shopping lists, or some other cover text. For example, the hidden message may be in invisible ink between the visible lines of a private letter. Some implementations of steganography that lack a shared secret are forms of security through obscurity, whereas key-dependent steganographic schemes adhere to Kerckhoffs’s principle.[1]

The advantage of steganography over cryptography alone is that the intended secret message does not attract attention to itself as an object of scrutiny. Plainly visible encrypted messages—no matter how unbreakable—arouse interest, and may in themselves be incriminating in countries where encryption is illegal.[2] Thus, whereas cryptography is the practice of protecting the contents of a message alone, steganography is concerned with concealing the fact that a secret message is being sent, as well as concealing the contents of the message.”

H. H. Holmes. A really nice guy.

Herman Webster Mudgett (May 16, 1861 – May 7, 1896), better known under the name of Dr. Henry Howard Holmes or more commonly just H. H. Holmes, was one of the first documented serial killers in the modern sense of the term.[1][2] In Chicago, at the time of the 1893 World’s Columbian Exposition, Holmes opened a hotel which he had designed and built for himself specifically with murder in mind, and which was the location of many of his murders. While he confessed to 27 murders, of which nine were confirmed, his actual body count could be up to 200.[3] He brought an unknown number of his victims to his World’s Fair Hotel, located about 3 miles (4.8 km) west of the fair, which was held in Jackson Park. Besides being a serial killer, H. H. Holmes was also a successful con artist and a bigamist. […]

Holmes purchased an empty lot across from the drugstore where he built his three-story, block-long hotel building. Because of its enormous structure, local people dubbed it “The Castle”. The building was 162 feet long and 50 feet wide. […] The ground floor of the Castle contained Holmes’ own relocated drugstore and various shops, while the upper two floors contained his personal office and a labyrinth of rooms with doorways opening to brick walls, oddly-angled hallways, stairways leading to nowhere, doors that could only be opened from the outside and a host of other strange and deceptive constructions. Holmes was constantly firing and hiring different workers during the construction of the Castle, claiming that “they were doing incompetent work.” His actual reason was to ensure that he was the only one who fully understood the design of the building.[3]

Minnesota Starvation Experiment.

“The Minnesota Starvation Experiment […] was a clinical study performed at the University of Minnesota between November 19, 1944 and December 20, 1945. The investigation was designed to determine the physiological and psychological effects of severe and prolonged dietary restriction and the effectiveness of dietary rehabilitation strategies.

The motivation of the study was twofold: First, to produce a definitive treatise on the subject of human starvation based on a laboratory simulation of severe famine and, second, to use the scientific results produced to guide the Allied relief assistance to famine victims in Europe and Asia at the end of World War II. It was recognized early in 1944 that millions of people were in grave danger of mass famine as a result of the conflict, and information was needed regarding the effects of semi-starvation—and the impact of various rehabilitation strategies—if postwar relief efforts were to be effective.”

“most of the subjects experienced periods of severe emotional distress and depression.[1]:161 There were extreme reactions to the psychological effects during the experiment including self-mutilation (one subject amputated three fingers of his hand with an axe, though the subject was unsure if he had done so intentionally or accidentally).[5] Participants exhibited a preoccupation with food, both during the starvation period and the rehabilitation phase. Sexual interest was drastically reduced, and the volunteers showed signs of social withdrawal and isolation.[1]:123–124 […] One of the crucial observations of the Minnesota Starvation Experiment […] is that the physical effects of the induced semi-starvation during the study closely approximate the conditions experienced by people with a range of eating disorders such as anorexia nervosa and bulimia nervosa.”

Post-vasectomy pain syndrome. Vasectomy reversal is a risk people probably know about, but this one seems to also be worth being aware of if one is considering having a vasectomy.

Transport in the Soviet Union (‘good article’). A few observations from the article:

“By the mid-1970s, only eight percent of the Soviet population owned a car. […]  From 1924 to 1971 the USSR produced 1 million vehicles […] By 1975 only 8 percent of rural households owned a car. […] Growth of motor vehicles had increased by 224 percent in the 1980s, while hardcore surfaced roads only increased by 64 percent. […] By the 1980s Soviet railways had become the most intensively used in the world. Most Soviet citizens did not own private transport, and if they did, it was difficult to drive long distances due to the poor conditions of many roads. […] Road transport played a minor role in the Soviet economy, compared to domestic rail transport or First World road transport. According to historian Martin Crouch, road traffic of goods and passengers combined was only 14 percent of the volume of rail transport. It was only late in its existence that the Soviet authorities put emphasis on road construction and maintenance […] Road transport as a whole lagged far behind that of rail transport; the average distance moved by motor transport in 1982 was 16.4 kilometres (10.2 mi), while the average for railway transport was 930 km per ton and 435 km per ton for water freight. In 1982 there was a threefold increase in investment since 1960 in motor freight transport, and more than a thirtyfold increase since 1940.”

March 3, 2016 Posted by | Biology, Cryptography, History, language, Lectures, Random stuff, Wikipedia, Zoology | Leave a comment

A few lectures

The sound quality of this lecture is not completely optimal – there’s a recurring echo popping up now and then which I found slightly annoying – but this should not keep you from watching the lecture. It’s a quite good lecture, and very accessible – I don’t really think you even need to know anything about genetics to follow most of what he’s talking about here; as far as I can tell it’s a lecture intended for people who don’t really know much about population genetics. He introduces key concepts as they are needed and he does not go much into the technical details which might cause people trouble (this of course also makes the lecture somewhat superficial, but you can’t get everything). If you’re the sort of person who wants details not included in the lecture you’re probably already reading e.g. Razib Khan (who incidentally recently blogged/criticized a not too dissimilar paper from the one discussed in the lecture, dealing with South Asia)…

I must admit that I actually didn’t like this lecture very much, but I figured I might as well include it in this post anyway.

I found some questions included and some aspects of the coverage a bit ‘too basic’ for my taste, but other people interested in chess reading along here may like Anna’s approach better; like Krause’s lecture I think it’s an accessible lecture, despite the fact that it actually covers many lines in quite a bit of detail. It’s a long lecture but I don’t think you necessarily need to watch all of it in one go (…or at all?) – the analysis of the second game, the Kortschnoj-Gheorghiu game, starts around 45 minutes in so that might for example be a good place to include a break, if a break is required.

February 1, 2016 Posted by | Anthropology, Archaeology, Chess, Computer science, Evolutionary biology, Genetics, History, Lectures | Leave a comment

A few lectures

Below are three new lectures from the Institute of Advanced Study. As far as I’ve gathered they’re all from an IAS symposium called ‘Lens of Computation on the Sciences’ – all three lecturers are computer scientists, but you don’t have to be a computer scientist to watch these lectures.

Should computer scientists and economists band together more and try to use the insights from one field to help solve problems in the other field? Roughgarden thinks so, and provides examples of how this might be done/has been done. Applications discussed in the lecture include traffic management and auction design. I’m not sure how much of this lecture is easy to follow for people who don’t know anything about either topic (i.e., computer science and economics), but I found it not too difficult to follow – it probably helped that I’ve actually done work on a few of the things he touches upon in the lecture, such as basic auction theory, the fixed point theorems and related proofs, basic queueing theory and basic discrete maths/graph theory. Either way there are certainly much more technical lectures than this one available at the IAS channel.

I don’t have Facebook and I’m not planning on ever getting a FB account, so I’m not really sure I care about the things this guy is trying to do, but the lecturer does touch upon some interesting topics in network theory. Not a great lecture in my opinion and occasionally I think the lecturer ‘drifts’ a bit, talking without saying very much, but it’s also not a terrible lecture. A few times I was really annoyed that you can’t see where he’s pointing that damn laser pointer, but this issue should not stop you from watching the video, especially not if you have an interest in analytical aspects of how to approach and make sense of ‘Big Data’.

I’ve noticed that Scott Alexander has said some nice things about Scott Aaronson a few times, but until now I’ve never actually read any of the latter guy’s stuff or watched any lectures by him. I agree with Scott (Alexander) that Scott (Aaronson) is definitely a smart guy. This is an interesting lecture; I won’t pretend I understood all of it, but it has some thought-provoking ideas and important points in the context of quantum computing and it’s actually a quite entertaining lecture; I was close to laughing a couple of times.

January 8, 2016 Posted by | Computer science, Economics, Game theory, Lectures, Mathematics, Physics | Leave a comment

A few lectures

I was debating whether to post this, but considering how long it’s been since my last post I decided to do it. A large number of lectures have recently been uploaded by the Institute for Advanced Studies, and despite the fact that most of my ‘blogging-related activities’ these days relate to book reading I have watched a few of those lectures, and so I decided to post a couple of the lectures here:

I liked this lecture. Part II of the lecture in particular, starting around the 38 minute mark, dealt with stuff reasonably closely related to things I’d read about before (‘relatively’…) recently, back when I read Lammer’s text (blog coverage here); so although I didn’t remember the stuff covered in Lammer’s text in too much detail, it was definitely helpful to have worked with this stuff before. However I do believe you can watch the lecture and sort of understand what she’s talking about without knowing a great deal about these topics, at least if you don’t care too much about understanding all the details (I’d note that there are a lot of things going on ‘behind the scenes’ here, and that you can say a lot of stuff about topics closely related to this talk, like outgassing processes and how they relate to things like volcanism as well as e.g. the dynamic interactions between atmospheric molecules and the solar wind taking place in the early stages of stellar evolution). As is always the case for IAS lectures it’s really hard to hear the questions being asked and that’s annoying, but actually I think miss Schilchting is reasonably good at repeating the question or sort of answer them in a way that enables you to gather what’s ‘going on’; at least the fact that you can’t hear the questions is in my opinion a somewhat bigger problem in the lecture below (relatedly you can actually also see where the laser pointer is pointing in this lecture, at least some of the time – you can’t in the lecture below).

As mentioned this one was harder to follow, at least for me.

I hope to find time to blog a bit more in the days to come. One of several reasons why I’ve not blogged more than I have during the last weeks is that I recently realized that if I put in a bit of effort I’d be able to reach 150 books this year (I’m currently at 143 books, but very close to 144), with 50 non-fiction books (I think going for 52 would be a bit too much, but I’m not ruling it out yet – I’m currently at 47 non-fiction books (…but very close to 48)). I should note that I update the book post to which I link above much more often than I update ‘the blog’ in general with new posts. The reason why the ‘read 150 books this year goal’ is relevant is of course that every time I blog a book here on the blog, this takes away a substantial amount of time which I can’t spend actually reading books. Goodreads incidentally have recently made a nice ‘book of the year’ profile where you can see more details about the books I’ve read etc. From that profile I realized that my implicit working goal of reading 100 pages/day over the year has already been met (I’m currently at ~42.000 pages).

December 18, 2015 Posted by | Astronomy, Books, Lectures, Physics | Leave a comment

A couple of lectures and a little bit of random stuff

i. Two lectures from the Institute for Advanced Studies:

The IAS has recently uploaded a large number of lectures on youtube, and the ones I blog here are a few of those where you can actually tell from the title what the lecture is about; I find it outright weird that these people don’t include the topic covered in the lecture in their lecture titles.

As for the video above, as usual for the IAS videos it’s annoying that you can’t hear the questions asked by the audience, but the sound quality of this video is at least quite a bit better than the sound quality of the video below (which has a couple of really annoying sequences, in particular around the 15-16 minutes mark (it gets better), where the image is also causing problems, and in the last couple of minutes of the Q&A things are also not exactly optimal as the lecturer leaves the area covered by the camera in order to write something on the blackboard – but you don’t know what he’s writing and you can’t see the lecturer, because the camera isn’t following him). I found most of the above lecture easier to follow than I did the lecture posted below, though in either case you’ll probably not understand all of it unless you’re an astrophysicist – you definitely won’t in case of the latter lecture. I found it helpful to look up a few topics along the way, e.g. the wiki articles about the virial theorem (/also dealing with virial mass/radius), active galactic nucleus (this is the ‘AGN’ she refers to repeatedly), and the Tully–Fisher relation.

Given how many questions are asked along the way it’s really annoying that you in most cases can’t hear what people are asking about – this is definitely an area where there’s room for improvement in the context of the IAS videos. The lecture was not easy to follow but I figured along the way that I understood enough of it to make it worth watching the lecture to the end (though I’d say you’ll not miss much if you stop after the lecture – around the 1.05 hours mark – and skip the subsequent Q&A). I’ve relatively recently read about related topics, e.g. pulsar formation and wave- and fluid dynamics, and if I had not I probably would not have watched this lecture to the end.

ii. A update. I’m slowly working my way up to the ‘Running Dictionary’ rank (I’m only a walking dictionary at this point); here’s some stuff from my progress page:

I recently learned from a note added to a list that I’ve actually learned a very large proportion of all words available on, which probably also means that I may have been too harsh on the word selection algorithm in past posts here on the blog; if there aren’t (/m)any new words left to learn it should not be surprising that the algorithm presents me with words I’ve already mastered, and it’s not the algorithm’s fault that there aren’t more words available for me to learn (well, it is to the extent that you’re of the opinion that questions should be automatically created by the algorithm as well, but I don’t think we’re quite there yet at this point). The aforementioned note was added in June, and here’s the important part: “there are words on your list that can’t teach yet. can teach over 12,000 words, but sadly, these aren’t among them”. ‘Over 12.000’ – and I’ve mastered 11.300. When the proportion of mastered words is this high, not only will the default random word algorithm mostly present you with questions related to words you’ve already mastered; but it actually also starts to get hard to find lists with many words you’ve not already mastered – I’ll often load lists with one hundred words and then realize that I’ve mastered every word on the list. This is annoying if you have a desire to continually be presented with both new words as well as old ones. Unless increases the rate with which they add new words I’ll run out of new words to learn, and if that happens I’m sure it’ll be much more difficult for me to find motivation to use the site.

With all that stuff out of the way, if you’re not a regular user of the site I should note – again – that it’s an excellent resource if you desire to increase your vocabulary. Below is a list of words I’ve encountered on the site in recent weeks(/months?):

Copaceticfrumpyelisiontermagantharridanquondam, funambulist, phantasmagoriaeyelet, cachinnate, wilt, quidnunc, flocculent, galoot, frangible, prevaricate, clarion, trivet, noisome, revenant, myrmidon (I have included this word once before in a post of this type, but it is in my opinion a very nice word with which more people should be familiar…), debenture, teeter, tart, satiny, romp, auricular, terpsichorean, poultice, ululation, fusty, tangy, honorarium, eyas, bumptious, muckraker, bayou, hobble, omphaloskepsis, extemporize, virago, rarefaction, flibbertigibbet, finagle, emollient.

iii. I don’t think I’d do things exactly the way she’s suggesting here, but the general idea/approach seems to me appealing enough for it to be worth at least keeping in mind if I ever decide to start dating/looking for a partner.

iv. Some wikipedia links:

Tarrare (featured). A man with odd eating habits and an interesting employment history (“Dr. Courville was keen to continue his investigations into Tarrare’s eating habits and digestive system, and approached General Alexandre de Beauharnais with a suggestion that Tarrare’s unusual abilities and behaviour could be put to military use.[9] A document was placed inside a wooden box which was in turn fed to Tarrare. Two days later, the box was retrieved from his excrement, with the document still in legible condition.[9][17] Courville proposed to de Beauharnais that Tarrare could thus serve as a military courier, carrying documents securely through enemy territory with no risk of their being found if he were searched.” Yeah…).

Cauda equina syndromeCastleman’s disease, Astereognosis, Familial dysautonomia, Homonymous hemianopsia, Amaurosis fugax. All of these are of course related to content covered in the Handbook.

1740 Batavia massacre (featured).

v. I am also fun.

October 30, 2015 Posted by | Astronomy, History, Immunology, language, Lectures, Medicine, Neurology, Personal, Physics, Random stuff, Wikipedia | Leave a comment

A few lectures

This one was mostly review for me, but there was also some new stuff and it was a ‘sort of okay’ lecture even if I was highly skeptical about a few points covered. I was debating whether to even post the lecture on account of those points of contention, but I figured that by adding a few remarks below I could justify doing it. So below a few skeptical comments relating to content covered in the lecture:

a) 28-29 minutes in he mentions that the cutoff for hypertension in diabetics is a systolic pressure above 130. Here opinions definitely differ, and opinions about treatment cutoffs differ; in the annual report from the Danish Diabetes Database they follow up on whether hospitals and other medical decision-making units are following guidelines (I’ve talked about the data on the blog, e.g. here), and the BP goal of involved decision-making units evaluated is currently whether diabetics with systolic BP above 140 receive antihypertensive treatment. This recent Cochrane review concluded that: “At the present time, evidence from randomized trials does not support blood pressure targets lower than the standard targets in people with elevated blood pressure and diabetes” and noted that: “The effect of SBP targets on mortality was compatible with both a reduction and increase in risk […] Trying to achieve the ‘lower’ SBP target was associated with a significant increase in the number of other serious adverse events”.

b) Whether retinopathy screenings should be conducted yearly or biennially is also contested, and opinions differ – this is not mentioned in the lecture, but I sort of figure maybe it should have been. There’s some evidence that annual screening is better (see e.g. this recent review), but the evidence base is not great and clinical outcomes do not seem to differ much in general; as noted in the review, “Observational and economic modelling studies in low-risk patients show little difference in clinical outcomes between screening intervals of 1 year or 2 years”. To stratify based on risk seems desirable from a cost-effectiveness standpoint, but how to stratify optimally seems to not be completely clear at the present point in time.

c) The Somogyi phenomenon is highly contested, and I was very surprised about his coverage of this topic – ‘he’s a doctor lecturing on this topic, he should know better’. As the wiki notes: “Although this theory is well known among clinicians and individuals with diabetes, there is little scientific evidence to support it.” I’m highly skeptical, and I seriously question the advice of lowering insulin in the context of morning hyperglycemia. As observed in Cryer’s text: “there is now considerable evidence against the Somogyi hypothesis (Guillod et al. 2007); morning hyperglycemia is the result of insulin lack, not post-hypoglycemic insulin resistance (Havlin and Cryer 1987; Tordjman et al. 1987; Hirsch et al. 1990). There is a dawn phenomenon—a growth hormone–mediated increase in the nighttime to morning plasma glucose concentration (Campbell et al. 1985)—but its magnitude is small (Periello et al. 1991).”

I decided not to embed this lecture in the post mainly because the resolution is unsatisfactorily low so that a substantial proportion of the visual content is frankly unintelligible; I figured this would bother others more than it did me and that a semi-satisfactory compromise solution in terms of coverage would be to link to the lecture, but not embed it here. You can hear what the lecturer is saying, which was enough for me, but you can’t make out stuff like effect differences, p-values, or many of the details in the graphic illustrations included. Despite the title of the lecture on youtube, the lecture actually mainly consists of a brief overview of pharmacological treatment options for diabetes.

If you want to skip the introduction, the first talk/lecture starts around 5 minutes and 30 seconds into the video. Note that despite the long running time of this video the lectures themselves only take about 50 minutes in total; the rest of it is post-lecture Q&A and discussion.

October 3, 2015 Posted by | Diabetes, Lectures, Mathematics, Medicine | Leave a comment

Random Stuff / Open Thread

This is not a very ‘meaty’ post, but it’s been a long time since I had one of these and I figured it was time for another one. As always links and comments are welcome.

i. The unbearable accuracy of stereotypes. I made a mental note of reading this paper later a long time ago, but I’ve been busy with other things. Today I skimmed it and decided that it looks interesting enough to give it a detailed read later. Some remarks from the summary towards the end of the paper:

“The scientific evidence provides more evidence of accuracy than of inaccuracy in social stereotypes. The most appropriate generalization based on the evidence is that people’s beliefs about groups are usually moderately to highly accurate, and are occasionally highly inaccurate. […] This pattern of empirical support for moderate to high stereotype accuracy is not unique to any particular target or perceiver group. Accuracy has been found with racial and ethnic groups, gender, occupations, and college groups. […] The pattern of moderate to high stereotype accuracy is not unique to any particular research team or methodology. […] This pattern of moderate to high stereotype accuracy is not unique to the substance of the stereotype belief. It occurs for stereotypes regarding personality traits, demographic characteristics, achievement, attitudes, and behavior. […] The strong form of the exaggeration hypothesis – either defining stereotypes as exaggerations or as claiming that stereotypes usually lead to exaggeration – is not supported by data. Exaggeration does sometimes occur, but it does not appear to occur much more frequently than does accuracy or underestimation, and may even occur less frequently.”

I should perhaps note that this research is closely linked to Funder’s research on personality judgment, which I’ve previously covered on the blog here and here.

ii. I’ve spent approximately 150 hours on altogether at this point (having ‘mastered’ ~10.200 words in the process). A few words I’ve recently encountered on the site: Nescience (note to self: if someone calls you ‘nescient’ during a conversation, in many contexts that’ll be an insult, not a compliment) (Related note to self: I should find myself some smarter enemies, who use words like ‘nescient’…), eristic, carrel, oleaginous, decal, gable, epigone, armoire, chalet, cashmere, arrogate, ovine.

iii. why p = .048 should be rare (and why this feels counterintuitive).

iv. A while back I posted a few comments on SSC and I figured I might as well link to them here (at least it’ll make it easier for me to find them later on). Here is where I posted a few comments on a recent study dealing with Ramadan-related IQ effects, a topic which I’ve covered here on the blog before, and here I discuss some of the benefits of not having low self-esteem.

On a completely unrelated note, today I left a comment in a reddit thread about ‘Books That Challenged You / Made You See the World Differently’ which may also be of interest to readers of this blog. I realized while writing the comment that this question is probably getting more and more difficult for me to answer as time goes by. It really all depends upon what part of the world you want to see in a different light; which aspects you’re most interested in. For people wondering about where the books about mathematics and statistics were in that comment (I do like to think these fields play some role in terms of ‘how I see the world‘), I wasn’t really sure which book to include on such topics, if any; I can’t think of any single math or stats textbook that’s dramatically changed the way I thought about the world – to the extent that my knowledge about these topics has changed how I think about the world, it’s been a long drawn-out process.

v. Chess…

People who care the least bit about such things probably already know that a really strong tournament is currently being played in St. Louis, the so-called Sinquefield Cup, so I’m not going to talk about that here (for resources and relevant links, go here).

I talked about the strong rating pools on ICC not too long ago, but one thing I did not mention when discussing this topic back then was that yes, I also occasionally win against some of those grandmasters the rating pool throws at me – at least I’ve won a few times against GMs by now in bullet. I’m aware that for many ‘serious chess players’ bullet ‘doesn’t really count’ because the time dimension is much more important than it is in other chess settings, but to people who think skill doesn’t matter much in bullet I’d say they should have a match with Hikaru Nakamura and see how well they do against him (if you’re interested in how that might turn out, see e.g. this video – and keep in mind that at the beginning of the video Nakamura had already won 8 games in a row, out of 8, against his opponent in the first games, who incidentally is not exactly a beginner). The skill-sets required do not overlap perfectly between bullet and classical time control games, but when I started playing bullet online I quickly realized that good players really require very little time to completely outplay people who just play random moves (fast). Below I have posted a screencap I took while kibitzing a game of one of my former opponents, an anonymous GM from Germany, against whom I currently have a 2.5/6 score, with two wins, one draw, and three losses (see the ‘My score vs CPE’ box).

Kibitzing GMs(click to view full size).

I like to think of a score like this as at least some kind of accomplishment, though admittedly perhaps not a very big one.

Also in chess-related news, I’m currently reading Jesús de la Villa’s 100 Endgames book, which Christof Sielecki has said some very nice things about. A lot of the stuff I’ve encountered so far is stuff I’ve seen before, positions I’ve already encountered and worked on, endgame principles I’m familiar with, etc., but not all of it is known stuff and I really like the structure of the book. There are a lot of pages left, and as it is I’m planning to read this book from cover to cover, which is something I usually do not do when I read chess books (few people do, judging from various comments I’ve seen people make in all kinds of different contexts).

Lastly, a lecture:

August 25, 2015 Posted by | Biology, Books, Chess, language, Lectures, Personal, Psychology, Statistics | 2 Comments

A few lectures

The Institute for Advanced Studies recently released a number of new lectures on youtube and I’ve watched a few of them.

Both this lecture and the one below start abruptly with no introduction, but I don’t think much stuff was covered before the beginning of this recording. The stuff in both lectures is ‘reasonably’ closely related to content covered in the book on pulsars/supernovae/neutron stars by McNamara which I recently finished (goodreads link) (…for some definitions of ‘reasonably’ I should perhaps add – it’s not that closely related, and for example Ramirez’ comment around the 50 minute mark that they’re disregarding magnetic fields seemed weird to me in the context of McNamara’s coverage). The first lecture was definitely much easier for me to follow than was the last one. The fact that you can’t hear the questions being asked I found annoying, but there aren’t that many questions being asked along the way. I was surprised to learn via google that Ramirez seems to be affiliated with the Niels Bohr Institute of Copenhagen (link).

Here’s a third lecture from the IAS:

I really didn’t think much of this lecture, but some of you might like it. It’s very non-technical compared to the first two lectures above, and unlike them the video recording did not start abruptly in the ‘middle’ of the lecture – which in this case on the other hand also means that you can actually easily skip the first 6-7 minutes without missing out on anything. Given the stuff he talks about in roughly the last 10 minutes of the lecture (aside from the concluding remarks) this is probably a reasonable place to remind you that Feynman’s lectures on the character of physical law are available on youtube and uploaded on this blog (see the link). If you have not watched those lectures, I actually think you should probably do that before watching a lecture like the one above – it’s in all likelihood a better use of your time. If you’re curious about things like cosmological scales and haven’t watched any of videos in the Khan Academy cosmology and astronomy lecture series, this is incidentally a good place to go have a look; the first few videos in the lecture series are really nice. Tegmark talks in his lecture about how we’ve underestimated how large the universe is, but I don’t really think the lecture adequately conveys just how mindbogglingly large the universe is, and I think Salman Khan’s lectures are much better if you want to get ‘a proper perspective’ of these things, to the extent that obtaining a ‘proper perspective’ is even possible given the limitations of the human mind.

Lastly, a couple more lectures from khanacademymedicine:

This is a neat little overview, especially if you’re unfamiliar with the topic.

July 24, 2015 Posted by | Astronomy, Lectures, Medicine, Pharmacology, Physics, Psychology | Leave a comment

Random stuff

It’s been a while since I posted anything here so I figured I should at least post something…

i. A few Khan Academy videos I watched a while back:

(No comments)

(Bookmark remark: (‘Not completely devoid of slight inaccuracies as usual – e.g. in meningitis, neck stiffness is not as much as symptom as it is a clinical sign (see Chamberlain’s symptoms and signs…))’

(Bookmark remark: ‘Very simplified, but not terrible’)

(No comments)

ii. I previously read the wiki on strategic bombing during WW2, but the article did not really satisfy my curiosity and it turns out that the wiki also has a great (featured) article about Air raids on Japan (a topic not covered in a great amount of detail in the aforementioned wiki article). A few random observations from the article:

“Overall, the attacks in May destroyed 94 square miles (240 km2) of buildings, which was equivalent to one seventh of Japan’s total urban area.”

“In Tokyo, Osaka, Nagoya, Yokohama, Kobe, and Kawasaki, “over 126,762 people were killed … and a million and a half dwellings and over 105 square miles (270 km2) of urban space were destroyed.”[136] In Tokyo, Osaka and Nagoya, “the areas leveled (almost 100 square miles (260 km2)) exceeded the areas destroyed in all German cities by both the American and English air forces (approximately 79 square miles (200 km2)).”[136]

“In financial terms, the Allied air campaign and attacks on merchant ships destroyed between one third and a quarter of Japan’s wealth.[289]

“Approximately 40 percent of the urban area of the 66 cities subjected to area attacks were destroyed.[290] This included the loss of about 2.5 million housing units, which rendered 8.5 million people homeless.”

iii. A few longer lectures I’ve watched recently but did not think were particularly good: The Fortress (GM Akobian, Chess), Safety in the Nuclear Industry (Philip Thomas, Gresham College), War, Health and Medicine: The medical lessons of World War I (Mark Harrison, Gresham College – topic had potential, somehow did not like ‘the delivery’; others may find it worth watching).

iv. I play a lot of (too much) chess these days, so I guess it makes sense to post a little on this topic as well. Here’s a list of some of my recent opponents on the ICC: GM Zurab Azmaiparashvili, IM Jerzy Slaby, IM Petar Gojkovic, GM Goran Kosanovic, IM Jeroen Bosch, WGM Alla Grinfeld. I recall encountering a few titled players when I started out on the ICC and my rating was still adjusting and stabilizing, but now I’ve sort of fixed at a level around 1700-1800 in both the 1, 3 and 5 minute pools – sometimes a bit higher, sometimes a bit lower (and I’ve played relatively few 5 minute games so far)). This is a level where at least in bullet some of the semi-regular opponents I’ll meet in the rating pool are guys like these. I was quite dissatisfied with my play when I started out on the ICC because I hadn’t realized how tough it is to maintain a high rating there; having a closer look at which sort of opponents I was actually facing gradually made me realize I was probably doing quite well, all things considered. Lately I’ve been thinking that I have probably even been doing quite a bit better than I’d thought I had. See also this and this link. I’ve gradually concluded that I’m probably never ‘going back’ now that I’ve familiarized myself with the ICC server.

And yes, I do occasionally win against opposition like that, also on position – below an example from a recent game against a player not on the list above (there are quite a few anonymous title-holders as well on the server):

Click to view full size – the list to the lower left is a list of other players online on the server at that point in time, ordered by rating; as should be clear, lots of title-holders have relatively low ratings (I’m not completely sure which rating pool was displayed in the sidebar at that time, but the defaults on display for me are 5- or 3-minutes, so for example the international master ‘softrain’ thus had either a 3 or 5 minute rating of 1799 at that time. Do note that ICC requires proof for titles to display on the server; random non-titled players do not display as titleholders on the ICC (actually the formally approved titled accounts obviously do not account for all accounts held by title-holders as some titled players on the server use accounts which do not give away the fact that they have a title).

Here’s another very nice illustration of how tough the X-minute pools are (/how strong the players playing on the ICC are):

Wang Hao
Again, click to view in full size. This is Chinese Grandmaster Wang Hao‘s ICC account. Wang Hao is currently #39 on the FIDE list of active chess players in the world, with a FIDE rating above 2700. Even his 5-minute rating on the ICC, based on more than a thousand games, is below 2300, and his current 3 minute rating is barely above 2000. With numbers like those, I currently feel quite satisfied with my 1700-1800 ratings (although I know I should be spending less time on chess than I currently do).

v. A few words I’ve recently encountered on Anaphora, usufruct, mimesis, amanuensis, peculate, elide, ataraxia, myrmidon, velleity.

vi. A few other wiki links: Fritz Haber, Great Stink (featured), Edward Low (a really nice guy, it seems – “A story describes Low burning a French cook alive, saying he was a “greasy fellow who would fry well”, and another tells he once killed 53 Spanish captives with his cutlass.[6]“), 1940 Soviet ultimatum to Lithuania (‘good article’).

vii. A really cute paper from the 2013 Christmas edition of the British Medical Journal: Were James Bond’s drinks shaken because of alcohol induced tremor? Here’s the abstract:

Objective To quantify James Bond’s consumption of alcohol as detailed in the series of novels by Ian Fleming.

Design Retrospective literature review.

Setting The study authors’ homes, in a comfy chair.

Participants Commander James Bond, 007; Mr Ian Lancaster Fleming.

Main outcome measures Weekly alcohol consumption by Commander Bond.

Methods All 14 James Bond books were read by two of the authors. Contemporaneous notes were taken detailing every alcoholic drink taken. Predefined alcohol unit levels were used to calculate consumption. Days when Bond was unable to consume alcohol (such as through incarceration) were noted.

Results After exclusion of days when Bond was unable to drink, his weekly alcohol consumption was 92 units a week, over four times the recommended amount. His maximum daily consumption was 49.8 units. He had only 12.5 alcohol free days out of 87.5 days on which he was able to drink.

Conclusions James Bond’s level of alcohol intake puts him at high risk of multiple alcohol related diseases and an early death. The level of functioning as displayed in the books is inconsistent with the physical, mental, and indeed sexual functioning expected from someone drinking this much alcohol. We advise an immediate referral for further assessment and treatment, a reduction in alcohol consumption to safe levels, and suspect that the famous catchphrase “shaken, not stirred” could be because of alcohol induced tremor affecting his hands.”

viii. A couple of other non-serious links which I found hilarious:
1) The Prof(essor) or Hobo quiz (via SSC).
2) Today’s SMBC. I’ll try to remember the words in the votey in the highly unlikely case I’ll ever have use for them – in my opinion it would be a real tragedy if one were to miss an opportunity to make a statement like that, given that it was at all suitable to the situation at hand..

July 6, 2015 Posted by | Chess, Diabetes, Epidemiology, History, Immunology, Infectious disease, Khan Academy, Lectures, Medicine, Personal | Leave a comment

A few lectures

This one is not quite new, but I have never seen it or blogged it before. The sound is not completely optimal and as is so often the case for lectures like these it’s at times slightly annoying that you can’t tell what she’s pointing at when she’s talking about the slides, but these issues are relatively minor and should not keep you from watching the lecture.

This is a really nice introduction to some main ideas in the Nimzo Indian defence.

June 10, 2015 Posted by | Astronomy, Chess, Lectures | Leave a comment


Sorry for the infrequent updates. I realized blogging Wodehouse books takes more time than I’d imagined, so posting this sort of stuff is probably a better idea.

i. Dunkirk evacuation (wikipedia ‘good article’). Fascinating article, as are a few of the related ones which I’ve also been reading (e.g. Operation Ariel).

“On the first day of the evacuation, only 7,669 men were evacuated, but by the end of the eighth day, a total of 338,226 soldiers had been rescued by a hastily assembled fleet of over 800 boats. Many of the troops were able to embark from the harbour’s protective mole onto 39 British destroyers and other large ships, while others had to wade out from the beaches, waiting for hours in the shoulder-deep water. Some were ferried from the beaches to the larger ships by the famous little ships of Dunkirk, a flotilla of hundreds of merchant marine boats, fishing boats, pleasure craft, and lifeboats called into service for the emergency. The BEF lost 68,000 soldiers during the French campaign and had to abandon nearly all of their tanks, vehicles, and other equipment.”

One way to make sense of the scale of the operations here is to compare them with the naval activities on D-day four years later. The British evacuated more people from France during three consecutive days in 1940 (30th and 31st of May, and 1st of June) than the Allies (Americans and British combined) landed on D-day four years later, and the British evacuated roughly as many people on the 31st of May (68,014) as they landed by sea on D-day (75,215). Here’s a part of the story I did not know:

“Three British divisions and a host of logistic and labour troops were cut off to the south of the Somme by the German “race to the sea”. At the end of May, a further two divisions began moving to France with the hope of establishing a Second BEF. The majority of the 51st (Highland) Division was forced to surrender on 12 June, but almost 192,000 Allied personnel, 144,000 of them British, were evacuated through various French ports from 15–25 June under the codename Operation Ariel.[104] […] More than 100,000 evacuated French troops were quickly and efficiently shuttled to camps in various parts of southwestern England, where they were temporarily lodged before being repatriated.[106] British ships ferried French troops to Brest, Cherbourg, and other ports in Normandy and Brittany, although only about half of the repatriated troops were deployed against the Germans before the surrender of France. For many French soldiers, the Dunkirk evacuation represented only a few weeks’ delay before being killed or captured by the German army after their return to France.[107]

ii. A pretty awesome display by the current world chess champion:

If you feel the same way I do about Maurice Ashley, you’ll probably want to skip the first few minutes of this video. Don’t miss the games, though – this is great stuff. Do keep in mind when watching this video that the clock is a really important part of this event; other players in the past have played a lot more people at the same time while blindfolded than Carlsen does here – “Although not a full-time chess professional [Najdorf] was one of the world’s leading chess players in the 1950s and 1960s and he excelled in playing blindfold chess: he broke the world record twice, by playing blindfold 40 games in Rosario, 1943,[8] and 45 in São Paulo, 1947, becoming the world blindfold chess champion” (link) – but a game clock changes things a lot. A few comments and discussion here.
In very slightly related news, I recently got in my first win against a grandmaster in a bullet game on the ICC.

iii. Gastric-brooding frog.


“The genus was unique because it contained the only two known frog species that incubated the prejuvenile stages of their offspring in the stomach of the mother.[3] […] What makes these frogs unique among all frog species is their form of parental care. Following external fertilization by the male, the female would take the eggs or embryos into her mouth and swallow them.[19] […] Eggs found in females measured up to 5.1 mm in diameter and had large yolk supplies. These large supplies are common among species that live entirely off yolk during their development. Most female frogs had around 40 ripe eggs, almost double that of the number of juveniles ever found in the stomach (21–26). This means one of two things, that the female fails to swallow all the eggs or the first few eggs to be swallowed are digested. […] During the period that the offspring were present in the stomach the frog would not eat. […] The birth process was widely spaced and may have occurred over a period of as long as a week. However, if disturbed the female may regurgitate all the young frogs in a single act of propulsive vomiting.”

Fascinating creatures.. Unfortunately they’re no longer around (they’re classified as extinct).

iv. I’m sort of conflicted about what to think about this:

“Epidemiological studies show that patients with type-2-diabetes (T2DM) and individuals with a diabetes-independent elevation in blood glucose have an increased risk for developing dementia, specifically dementia due to Alzheimer’s disease (AD). These observations suggest that abnormal glucose metabolism likely plays a role in some aspects of AD pathogenesis, leading us to investigate the link between aberrant glucose metabolism, T2DM, and AD in murine models. […] Recent epidemiological studies demonstrate that individuals with type-2 diabetes (T2DM) are 2–4 times more likely to develop AD (35), individuals with elevated blood glucose levels are at an increased risk to develop dementia (5), and those with elevated blood glucose levels have a more rapid conversion from mild cognitive impairment (MCI) to AD (6), suggesting that disrupted glucose homeostasis could play a […] causal role in AD pathogenesis. Although several prominent features of T2DM, including increased insulin resistance and decreased insulin production, are at the forefront of AD research (710), questions regarding the effects of elevated blood glucose independent of insulin resistance on AD pathology remain largely unexplored. In order to investigate the potential role of glucose metabolism in AD, we combined glucose clamps and in vivo microdialysis as a method to measure changes in brain metabolites in awake, freely moving mice during a hyperglycemic challenge. Our findings suggest that acute hyperglycemia raises interstitial fluid (ISF) Aβ levels by altering neuronal activity, which increases Aβ production. […] Since extracellular Aβ, and subsequently tau, aggregate in a concentration-dependent manner during the preclinical period of AD while individuals are cognitively normal (27), our findings suggest that repeated episodes of transient hyperglycemia, such as those found in T2DM, could both initiate and accelerate plaque accumulation. Thus, the correlation between hyperglycemia and increased ISF Aβ provides one potential explanation for the increased risk of AD and dementia in T2DM patients or individuals with elevated blood glucose levels. In addition, our work suggests that KATP channels within the hippocampus act as metabolic sensors and couple alterations in glucose concentrations with changes in electrical activity and extracellular Aβ levels. Not only does this offer one mechanistic explanation for the epidemiological link between T2DM and AD, but it also provides a potential therapeutic target for AD. Given that FDA-approved drugs already exist for the modulation of KATP channels and previous work demonstrates the benefits of sulfonylureas for treating animal models of AD (26), the identification of these channels as a link between hyperglycemia and AD pathology creates an avenue for translational research in AD.”

Why am I conflicted? Well, on the one hand it’s nice to know that they’re making progress in terms of figuring out why people get Alzheimer’s and potential therapeutic targets are being identified. On the other hand this – “our findings suggest that repeated episodes of transient hyperglycemia […] could both initiate and accelerate plaque accumulation” – is bad news if you’re a type 1 diabetic (I’d much rather have them identify risk factors to which I’m not exposed).

v. I recently noticed that Khan Academy has put up some videos about diabetes. From the few ones I’ve had a look at they don’t seem to contain much stuff I don’t already know so I’m not sure I’ll explore this playlist in any more detail, but I figured I might as well share a few of the videos here; the first one is about the pathophysiology of type 1 diabetes and the second one’s about diabetic nephropathy (kidney disease):

vi. On Being the Right Size, by J. B. S. Haldane. A neat little text. A few quotes:

“To the mouse and any smaller animal [gravity] presents practically no dangers. You can drop a mouse down a thousand-yard mine shaft; and, on arriving at the bottom, it gets a slight shock and walks away, provided that the ground is fairly soft. A rat is killed, a man is broken, a horse splashes. For the resistance presented to movement by the air is proportional to the surface of the moving object. Divide an animal’s length, breadth, and height each by ten; its weight is reduced to a thousandth, but its surface only to a hundredth. So the resistance to falling in the case of the small animal is relatively ten times greater than the driving force.

An insect, therefore, is not afraid of gravity; it can fall without danger, and can cling to the ceiling with remarkably little trouble. It can go in for elegant and fantastic forms of support like that of the daddy-longlegs. But there is a force which is as formidable to an insect as gravitation to a mammal. This is surface tension. A man coming out of a bath carries with him a film of water of about one-fiftieth of an inch in thickness. This weighs roughly a pound. A wet mouse has to carry about its own weight of water. A wet fly has to lift many times its own weight and, as everyone knows, a fly once wetted by water or any other liquid is in a very serious position indeed. An insect going for a drink is in as great danger as a man leaning out over a precipice in search of food. If it once falls into the grip of the surface tension of the water—that is to say, gets wet—it is likely to remain so until it drowns. A few insects, such as water-beetles, contrive to be unwettable; the majority keep well away from their drink by means of a long proboscis. […]

It is an elementary principle of aeronautics that the minimum speed needed to keep an aeroplane of a given shape in the air varies as the square root of its length. If its linear dimensions are increased four times, it must fly twice as fast. Now the power needed for the minimum speed increases more rapidly than the weight of the machine. So the larger aeroplane, which weighs sixty-four times as much as the smaller, needs one hundred and twenty-eight times its horsepower to keep up. Applying the same principle to the birds, we find that the limit to their size is soon reached. An angel whose muscles developed no more power weight for weight than those of an eagle or a pigeon would require a breast projecting for about four feet to house the muscles engaged in working its wings, while to economize in weight, its legs would have to be reduced to mere stilts. Actually a large bird such as an eagle or kite does not keep in the air mainly by moving its wings. It is generally to be seen soaring, that is to say balanced on a rising column of air. And even soaring becomes more and more difficult with increasing size. Were this not the case eagles might be as large as tigers and as formidable to man as hostile aeroplanes.

But it is time that we pass to some of the advantages of size. One of the most obvious is that it enables one to keep warm. All warmblooded animals at rest lose the same amount of heat from a unit area of skin, for which purpose they need a food-supply proportional to their surface and not to their weight. Five thousand mice weigh as much as a man. Their combined surface and food or oxygen consumption are about seventeen times a man’s. In fact a mouse eats about one quarter its own weight of food every day, which is mainly used in keeping it warm. For the same reason small animals cannot live in cold countries. In the arctic regions there are no reptiles or amphibians, and no small mammals. The smallest mammal in Spitzbergen is the fox. The small birds fly away in winter, while the insects die, though their eggs can survive six months or more of frost. The most successful mammals are bears, seals, and walruses.” [I think he’s a bit too categorical in his statements here and this topic is more contested today than it probably was when he wrote his text – see wikipedia’s coverage of Bergmann’s rule].

May 26, 2015 Posted by | Biology, Chess, Diabetes, Epidemiology, History, Khan Academy, Lectures, Medicine, Neurology, Wikipedia, Zoology | Leave a comment

Random stuff/Open Thread

i. A lecture on mathematical proofs:

ii. “In the fall of 1944, only seven percent of all bombs dropped by the Eighth Air Force hit within 1,000 feet of their aim point.”

From wikipedia’s article on Strategic bombing during WW2. The article has a lot of stuff. The ‘RAF estimates of destruction of “built up areas” of major German cities’ numbers in the article made my head spin – they didn’t bomb the Germans back to the stone age, but they sure tried. Here’s another observation from the article:

“After the war, the U.S. Strategic Bombing Survey reviewed the available casualty records in Germany, and concluded that official German statistics of casualties from air attack had been too low. The survey estimated that at a minimum 305,000 were killed in German cities due to bombing and estimated a minimum of 780,000 wounded. Roughly 7,500,000 German civilians were also rendered homeless.” (The German population at the time was roughly 70 million).

iii. Also war-related: Eddie Slovik:

Edward Donald “Eddie” Slovik (February 18, 1920 – January 31, 1945) was a United States Army soldier during World War II and the only American soldier to be court-martialled and executed for desertion since the American Civil War.[1][2]

Although over 21,000 American soldiers were given varying sentences for desertion during World War II, including 49 death sentences, Slovik’s was the only death sentence that was actually carried out.[1][3][4]

During World War II, 1.7 million courts-martial were held, representing one third of all criminal cases tried in the United States during the same period. Most of the cases were minor, as were the sentences.[2] Nevertheless, a clemency board, appointed by the Secretary of War in the summer of 1945, reviewed all general courts-martial where the accused was still in confinement.[2][5] That Board remitted or reduced the sentence in 85 percent of the 27,000 serious cases reviewed.[2] The death penalty was rarely imposed, and those cases typically were for rapes or murders. […] In France during World War I from 1917 to 1918, the United States Army executed 35 of its own soldiers, but all were convicted of rape and/or unprovoked murder of civilians and not for military offenses.[13] During World War II in all theaters of the war, the United States military executed 102 of its own soldiers for rape and/or unprovoked murder of civilians, but only Slovik was executed for the military offense of desertion.[2][14] […] of the 2,864 army personnel tried for desertion for the period January 1942 through June 1948, 49 were convicted and sentenced to death, and 48 of those sentences were voided by higher authority.”

What motivated me to read the article was mostly curiosity about how many people were actually executed for deserting during the war, a question I’d never encountered any answers to previously. The US number turned out to be, well, let’s just say it’s lower than I’d expected it would be. American soldiers who chose to desert during the war seem to have had much, much better chances of surviving the war than had soldiers who did not. Slovik was not a lucky man. On a related note, given numbers like these I’m really surprised desertion rates were not much higher than they were; presumably community norms (”desertion = disgrace’, which would probably rub off on other family members…’) played a key role here.

iv. Chess and infinity. I haven’t posted this link before even though the thread is a few months old, and I figured that given that I just had a conversation on related matters in the comment section of SCC (here’s a link) I might as well repost some of this stuff here. Some key points from the thread (I had to make slight formatting changes to the quotes because wordpress had trouble displaying some of the numbers, but the content is unchanged):

“Shannon has estimated the number of possible legal positions to be about 1043. The number of legal games is quite a bit higher, estimated by Littlewood and Hardy to be around 1010^5 (commonly cited as 1010^50 perhaps due to a misprint). This number is so large that it can’t really be compared with anything that is not combinatorial in nature. It is far larger than the number of subatomic particles in the observable universe, let alone stars in the Milky Way galaxy.

As for your bonus question, a typical chess game today lasts about 40­ to 60 moves (let’s say 50). Let us say that there are 4 reasonable candidate moves in any given position. I suspect this is probably an underestimate if anything, but let’s roll with it. That gives us about 42×50 ≈ 1060 games that might reasonably be played by good human players. If there are 6 candidate moves, we get around 1077, which is in the neighbourhood of the number of particles in the observable universe.”

“To put 1010^5 into perspective:

There are 1080 protons in the Universe. Now imagine inside each proton, we had a whole entire Universe. Now imagine again that inside each proton inside each Universe inside each proton, you had another Universe. If you count up all the protons, you get (1080 )3 = 10240, which is nowhere near the number we’re looking for.

You have to have Universes inside protons all the way down to 1250 steps to get the number of legal chess games that are estimated to exist. […]

Imagine that every single subatomic particle in the entire observable universe was a supercomputer that analysed a possible game in a single Planck unit of time (10-43 seconds, the time it takes light in a vacuum to travel 10-20 times the width of a proton), and that every single subatomic particle computer was running from the beginning of time up until the heat death of the Universe, 101000 years ≈ 1011 × 101000 seconds from now.

Even in these ridiculously favorable conditions, we’d only be able to calculate

1080 × 1043 × 1011 × 101000 = 101134

possible games. Again, this doesn’t even come close to 1010^5 = 10100000 .

Basically, if we ever solve the game of chess, it definitely won’t be through brute force.”

v. An interesting resource which a friend of mine recently shared with me and which I thought I should share here as well: Nature Reviews – Disease Primers.

vi. Here are some words I’ve recently encountered on augury, spangle, imprimatur, apperception, contrition, ensconce, impuissance, acquisitive, emendation, tintinnabulation, abalone, dissemble, pellucid, traduce, objurgation, lummox, exegesis, probity, recondite, impugn, viscid, truculence, appurtenance, declivity, adumbrate, euphony, educe, titivate, cerulean, ardour, vulpine.

May 16, 2015 Posted by | Chess, Computer science, History, Lectures, Mathematics | Leave a comment


i. World Happiness Report 2013. A few figures from the publication:

Fig 2.2

Fig 2.4

Fig 2.5

ii. Searching for Explanations: How the Internet Inflates Estimates of Internal Knowledge.

“As the Internet has become a nearly ubiquitous resource for acquiring knowledge about the world, questions have arisen about its potential effects on cognition. Here we show that searching the Internet for explanatory knowledge creates an illusion whereby people mistake access to information for their own personal understanding of the information. Evidence from 9 experiments shows that searching for information online leads to an increase in self-assessed knowledge as people mistakenly think they have more knowledge “in the head,” even seeing their own brains as more active as depicted by functional MRI (fMRI) images.”

A little more from the paper:

“If we go to the library to find a fact or call a friend to recall a memory, it is quite clear that the information we seek is not accessible within our own minds. When we go to the Internet in search of an answer, it seems quite clear that we are we consciously seeking outside knowledge. In contrast to other external sources, however, the Internet often provides much more immediate and reliable access to a broad array of expert information. Might the Internet’s unique accessibility, speed, and expertise cause us to lose track of our reliance upon it, distorting how we view our own abilities? One consequence of an inability to monitor one’s reliance on the Internet may be that users become miscalibrated regarding their personal knowledge. Self-assessments can be highly inaccurate, often occurring as inflated self-ratings of competence, with most people seeing themselves as above average [here’s a related link] […] For example, people overestimate their own ability to offer a quality explanation even in familiar domains […]. Similar illusions of competence may emerge as individuals become immersed in transactive memory networks. They may overestimate the amount of information contained in their network, producing a “feeling of knowing,” even when the content is inaccessible […]. In other words, they may conflate the knowledge for which their partner is responsible with the knowledge that they themselves possess (Wegner, 1987). And in the case of the Internet, an especially immediate and ubiquitous memory partner, there may be especially large knowledge overestimations. As people underestimate how much they are relying on the Internet, success at finding information on the Internet may be conflated with personally mastered information, leading Internet users to erroneously include knowledge stored outside their own heads as their own. That is, when participants access outside knowledge sources, they may become systematically miscalibrated regarding the extent to which they rely on their transactive memory partner. It is not that they misattribute the source of their knowledge, they could know full well where it came from, but rather they may inflate the sense of how much of the sum total of knowledge is stored internally.

We present evidence from nine experiments that searching the Internet leads people to conflate information that can be found online with knowledge “in the head.” […] The effect derives from a true misattribution of the sources of knowledge, not a change in understanding of what counts as internal knowledge (Experiment 2a and b) and is not driven by a “halo effect” or general overconfidence (Experiment 3). We provide evidence that this effect occurs specifically because information online can so easily be accessed through search (Experiment 4a–c).”

iii. Some words I’ve recently encountered on hortatory, adduce, obsequious, enunciate, ineluctable, guerdon, chthonic, condignphilippic, coruscate, exceptionable, colophon, lapidary, rubicund, frumpish, raiment, prorogue, sonorous, metonymy.


v. I have no idea how accurate this test of chess strength is, (some people in this thread argue that there are probably some calibration issues at the low end) but I thought I should link to it anyway. I’d be very cautious about drawing strong conclusions about over-the-board strength without knowing how they’ve validated the tool. In over-the-board chess you have at minimum a couple of minutes/move on average and this tool never gives you more than 30 seconds, so some slow players will probably suffer using this tool (I’d imagine this is why u/ViktorVamos got such a low estimate). For what it’s worth my Elo estimate was 2039 (95% CI: 1859, 2220).

In related news, I recently defeated my first IM – Pablo Garcia Castro – in a blitz (3 minutes/player) game. It actually felt a bit like an anticlimax and afterwards I was thinking that it would probably have felt like a bigger deal if I’d not lately been getting used to winning the occasional bullet game against IMs on the ICC. Actually I think my two wins against WIM Shiqun Ni during the same bullet session at the time felt like a bigger accomplishment, because that specific session was played during the Women’s World Chess Championship and I realized while looking up my opponent that this woman was actually stronger than one of the contestants who made it to the quarter-finals in that event (Meri Arabidze). On the other hand bullet isn’t really chess, so…

April 15, 2015 Posted by | Astronomy, Chess, Lectures, Papers, Psychology | 2 Comments

A few lectures

(This was a review lecture for me as I read a textbook on these topics a few months back going into quite a lot more detail – the post I link to has some relevant links if you’re curious to explore this topic further).

A few relevant links: Group (featured), symmetry group, Cayley table, Abelian group, Symmetry groups of Platonic solids, dual polyhedron, Lagrange’s theorem (group theory), Fermat’s little theorem. I think he was perhaps trying to cover a little bit too much ground in too little time by bringing up the RSA algorithm towards the end, but I’m sort of surprised how many people disliked the video; I don’t think it’s that bad.

The beginning of the lecture has a lot of remarks about Fourier‘s life which are in some sense not ‘directly related’ to the mathematics, and so if this is what you’re most interested in knowing more about you can probably skip the first 11 minutes or so of the lecture without missing out on much. The lecture is very non-technical compared to coverage like this, this, and this (…or this).

I think one thing worth mentioning here is that the lecturer is the author of a rather amazing book on the topic he talks about in the lecture.

April 2, 2015 Posted by | History, Lectures, Mathematics | Leave a comment

A few lectures



December 14, 2014 Posted by | Astronomy, Lectures, Physics | Leave a comment

Open Thread

It’s been a long time since I had one of these. Questions? Comments? Random observations?

I hate posting posts devoid of content, so here’s some random stuff:


If you think the stuff above is all fun and games I should note that the topic of chiralty, which is one of the things talked about in the lecture above, was actually covered in some detail in Gale’s book, which hardly is a book which spends a great deal of time talking about esoteric mathematical concepts. On a related note, the main reason why I have not blogged that book is incidentally that I lost all notes and highlights I’d made in the first 200 pages of the book when my computer broke down, and I just can’t face reading that book again simply in order to blog it. It’s a good book, with interesting stuff, and I may decide to blog it later, but I don’t feel like doing it at the moment; without highlights and notes it’s a real pain to blog a book, and right now it’s just not worth it to reread the book. Rereading books can be fun – I’ve incidentally been rereading Darwin lately and I may decide to blog this book soon; I imagine I might also choose to reread some of Asimov’s books before long – but it’s not much fun if you’re finding yourself having to do it simply because the computer deleted your work.

ii. Beyond Power Calculations: Assessing Type S (Sign) and Type M (Magnitude) Errors.

Here’s the abstract:

“Statistical power analysis provides the conventional approach to assess error rates when designing a research study. However, power analysis is flawed in that a narrow emphasis on statistical significance is placed as the primary focus of study design. In noisy, small-sample settings, statistically significant results can often be misleading. To help researchers address this problem in the context of their own studies, we recommend design calculations in which (a) the probability of an estimate being in the wrong direction (Type S [sign] error) and (b) the factor by which the magnitude of an effect might be overestimated (Type M [magnitude] error or exaggeration ratio) are estimated. We illustrate with examples from recent published research and discuss the largest challenge in a design calculation: coming up with reasonable estimates of plausible effect sizes based on external information.”

If a study has low power, you can get into a lot of trouble. Some problems are well known, others probably aren’t. A bit more from the paper:

“design calculations can reveal three problems:
1. Most obvious, a study with low power is unlikely to “succeed” in the sense of yielding a statistically significant result.
2. It is quite possible for a result to be significant at the 5% level — with a 95% confidence interval that entirely excludes zero — and for there to be a high chance, sometimes 40% or more, that this interval is on the wrong side of zero. Even sophisticated users of statistics can be unaware of this point — that the probability of a Type S error is not the same as the p value or significance level.[3]
3. Using statistical significance as a screener can lead researchers to drastically overestimate the magnitude of an effect (Button et al., 2013).

Design analysis can provide a clue about the importance of these problems in any particular case.”

“Statistics textbooks commonly give the advice that statistical significance is not the same as practical significance, often with examples in which an effect is clearly demonstrated but is very small […]. In many studies in psychology and medicine, however, the problem is the opposite: an estimate that is statistically significant but with such a large uncertainty that it provides essentially no information about the phenomenon of interest. […] There is a range of evidence to demonstrate that it remains the case that too many small studies are done and preferentially published when “significant.” We suggest that one reason for the continuing lack of real movement on this problem is the historic focus on power as a lever for ensuring statistical significance, with inadequate attention being paid to the difficulties of interpreting statistical significance in underpowered studies. Because insufficient attention has been paid to these issues, we believe that too many small studies are done and preferentially published when “significant.” There is a common misconception that if you happen to obtain statistical significance with low power, then you have achieved a particularly impressive feat, obtaining scientific success under difficult conditions.
However, that is incorrect if the goal is scientific understanding rather than (say) publication in a top journal. In fact, statistically significant results in a noisy setting are highly likely to be in the wrong direction and invariably overestimate the absolute values of any actual effect sizes, often by a substantial factor.”

iii. I’m sure most people who might be interested in following the match are already well aware that Anand and Carlsen are currently competing for the world chess championship, and I’m not going to talk about that match here. However I do want to mention to people interested in improving their chess that I recently came across this site, and that I quite like it. It only deals with endgames, but endgames are really important. If you don’t know much about endgames you may find the videos available here, here and here to be helpful.

iv. A link: Crosss Validated: “Cross Validated is a question and answer site for people interested in statistics, machine learning, data analysis, data mining, and data visualization.”

A friend recently told me about this resource. I knew about the existence of StackExchange, but I haven’t really spent much time there. These days I mostly stick to books and a few sites I already know about; I rarely look for new interesting stuff online. This also means you should not automatically assume I surely already know about X when you’re considering whether to tell me about X in an Open Thread.

November 18, 2014 Posted by | Chess, Lectures, Mathematics, Open Thread, Papers, Statistics | Leave a comment

Open Thread

It’s been a long time since I had one of these.

Some random stuff I’ve come across:

i. Reviews of Anything. Some pretty funny stuff there. Examples include:  Our solar system: 1 star. Reviews of this review. The 5 star Rating System: 9/10. Obese Americans, 1 out of 4. Spell Checker: 1 satr.


iii. The Bad Writing Contest. A quote from the link:

“The move from a structuralist account in which capital is understood to structure social relations in relatively homologous ways to a view of hegemony in which power relations are subject to repetition, convergence, and rearticulation brought the question of temporality into the thinking of structure, and marked a shift from a form of Althusserian theory that takes structural totalities as theoretical objects to one in which the insights into the contingent possibility of structure inaugurate a renewed conception of hegemony as bound up with the contingent sites and strategies of the rearticulation of power.”

In contexts where you socialize with people who write that way, dumbpiphanies may happen.


v. I’m not actually sure I liked this lecture very much (I was very much annoyed by the word ‘cristal’ in the slides in the last part of the lecture; he repeatedly misspells the word crystal in the slides. I find that kind of sloppiness irritating, because I tend to use the existence of spelling errors in lecture notes/slides in mathematical lectures as what might be termed a caution heuristic; if the lecturer did not bother to correct spelling errors, I figure he probably also didn’t bother to correct other errors in the slides – and if you start to think along the way that there might be errors in the slides, a lecture to me becomes less enjoyable to watch, especially when the lecture deals with complicated stuff which is hard enough to follow as it is), but I figured I might as well share it anyway:

vi. arXiv vs snarXiv.



September 30, 2014 Posted by | Lectures, Mathematics, Open Thread | 8 Comments