“A recent study estimated that 234 million surgical procedures requiring anaesthesia are performed worldwide annually. Anaesthesia is the largest hospital specialty in the UK, with over 12,000 practising anaesthetists […] In this book, I give a short account of the historical background of anaesthetic practice, a review of anaesthetic equipment, techniques, and medications, and a discussion of how they work. The risks and side effects of anaesthetics will be covered, and some of the subspecialties of anaesthetic practice will be explored.”

I liked the book, and I gave it three stars on goodreads; I was closer to four stars than two. Below I have added a few sample observations from the book, as well as what turned out in the end to be actually a quite considerable number of links (more than 60 it turned out, from a brief count) to topics/people/etc. discussed or mentioned in the text. I decided to spend a bit more time finding relevant links than I’ve previously done when writing link-heavy posts, so in this post I have not limited myself to wikipedia articles and I e.g. also link directly to primary literature discussed in the coverage. The links provided are, as usual, meant to be indicators of which kind of stuff is covered in the book, rather than an alternative to the book; some of the wikipedia articles in particular I assume are not very good (the main point of a link to a wikipedia article of questionable quality should probably be taken to be an indication that I consider ‘awareness of the existence of concept X’ to be of interest/important also to people who have not read this book, even if no great resource on the topic was immediately at hand to me).

Sample observations from the book:

“[G]eneral anaesthesia is not sleep. In physiological terms, the two states are very dissimilar. The term general anaesthesia refers to the state of unconsciousness which is deliberately produced by the action of drugs on the patient. Local anaesthesia (and its related terms) refers to the numbness produced in a part of the body by deliberate interruption of nerve function; this is typically achieved without affecting consciousness. […] The purpose of inhaling ether vapour [in the past] was so that surgery would be painless, not so that unconsciousness would necessarily be produced. However, unconsciousness and immobility soon came to be considered desirable attributes […] For almost a century, lying still was the only reliable sign of adequate anaesthesia.”

“The experience of pain triggers powerful emotional consequences, including fear, anger, and anxiety. A reasonable word for the emotional response to pain is ‘suffering’. Pain also triggers the formation of memories which remind us to avoid potentially painful experiences in the future. The intensity of pain perception and suffering also depends on the mental state of the subject at the time, and the relationship between pain, memory, and emotion is subtle and complex. […] The effects of adrenaline are responsible for the appearance of someone in pain: pale, sweating, trembling, with a rapid heart rate and breathing. Additionally, a hormonal storm is activated, readying the body to respond to damage and fight infection. This is known as the stress response. […] Those responses may be abolished by an analgesic such as morphine, which will counteract all those changes. For this reason, it is routine to use analgesic drugs in addition to anaesthetic ones. […] Typical anaesthetic agents are poor at suppressing the stress response, but analgesics like morphine are very effective. […] The hormonal stress response can be shown to be harmful, especially to those who are already ill. For example, the increase in blood coagulability which evolved to reduce blood loss as a result of injury makes the patient more likely to suffer a deep venous thrombosis in the leg veins.”

“If we monitor the EEG of someone under general anaesthesia, certain identifiable changes to the signal occur. In general, the frequency spectrum of the signal slows. […] Next, the overall power of the signal diminishes. In very deep general anaesthesia, short periods of electrical silence, known as burst suppression, can be observed. Finally, the overall randomness of the signal, its entropy, decreases. In short, the EEG of someone who is anaesthetized looks completely different from someone who is awake. […] Depth of anaesthesia is no longer considered to be a linear concept […] since it is clear that anaesthesia is not a single process. It is now believed that the two most important components of anaesthesia are unconsciousness and suppression of the stress response. These can be represented on a three-dimensional diagram called a response surface. [Here’s incidentally a recent review paper on related topics, US]”

“Before the widespread advent of anaesthesia, there were very few painkilling options available. […] Alcohol was commonly given as a means of enhancing the patient’s courage prior to surgery, but alcohol has almost no effect on pain perception. […] For many centuries, opium was the only effective pain-relieving substance known. […] For general anaesthesia to be discovered, certain prerequisites were required. On the one hand, the idea that surgery without pain was achievable had to be accepted as possible. Despite tantalizing clues from history, this idea took a long time to catch on. The few workers who pursued this idea were often openly ridiculed. On the other, an agent had to be discovered that was potent enough to render a patient suitably unconscious to tolerate surgery, but not so potent that overdose (hence accidental death) was too likely. This agent also needed to be easy to produce, tolerable for the patient, and easy enough for untrained people to administer. The herbal candidates (opium, mandrake) were too unreliable or dangerous. The next reasonable candidate, and every agent since, was provided by the proliferating science of chemistry.”

“Inducing anaesthesia by intravenous injection is substantially quicker than the inhalational method. Inhalational induction may take several minutes, while intravenous induction happens in the time it takes for the blood to travel from the needle to the brain (30 to 60 seconds). The main benefit of this is not convenience or comfort but patient safety. […] It was soon discovered that the ideal balance is to induce anaesthesia intravenously, but switch to an inhalational agent […] to keep the patient anaesthetized during the operation. The template of an intravenous induction followed by maintenance with an inhalational agent is still widely used today. […] Most of the drawbacks of volatile agents disappear when the patient is already anaesthetized [and] volatile agents have several advantages for maintenance. First, they are predictable in their effects. Second, they can be conveniently administered in known quantities. Third, the concentration delivered or exhaled by the patient can be easily and reliably measured. Finally, at steady state, the concentration of volatile agent in the patient’s expired air is a close reflection of its concentration in the patient’s brain. This gives the anaesthetist a reliable way of ensuring that enough anaesthetic is present to ensure the patient remains anaesthetized.”

“All current volatile agents are colourless liquids that evaporate into a vapour which produces general anaesthesia when inhaled. All are chemically stable, which means they are non-flammable, and not likely to break down or be metabolized to poisonous products. What distinguishes them from each other are their specific properties: potency, speed of onset, and smell. Potency of an inhalational agent is expressed as MAC, the minimum alveolar concentration required to keep 50% of adults unmoving in response to a standard surgical skin incision. MAC as a concept was introduced […] in 1963, and has proven to be a very useful way of comparing potencies of different anaesthetic agents. […] MAC correlates with observed depth of anaesthesia. It has been known for over a century that potency correlates very highly with lipid solubility; that is, the more soluble an agent is in lipid […], the more potent an anaesthetic it is. This is known as the Meyer-Overton correlation […] Speed of onset is inversely proportional to water solubility. The less soluble in water, the more rapidly an agent will take effect. […] Where immobility is produced at around 1.0 MAC, amnesia is produced at a much lower dose, typically 0.25 MAC, and unconsciousness at around 0.5 MAC. Therefore, a patient may move in response to a surgical stimulus without either being conscious of the stimulus, or remembering it afterwards.”

“The most useful way to estimate the body’s physiological reserve is to assess the patient’s tolerance for exercise. Exercise is a good model of the surgical stress response. The greater the patient’s tolerance for exercise, the better the perioperative outcome is likely to be […] For a smoker who is unable to quit, stopping for even a couple of days before the operation improves outcome. […] Dying ‘on the table’ during surgery is very unusual. Patients who die following surgery usually do so during convalescence, their weakened state making them susceptible to complications such as wound breakdown, chest infections, deep venous thrombosis, and pressure sores.”

Mechanical ventilation is based on the principle of intermittent positive pressure ventilation (IPPV), gas being ‘blown’ into the patient’s lungs from the machine. […] Inflating a patient’s lungs is a delicate process. Healthy lung tissue is fragile, and can easily be damaged by overdistension (barotrauma). While healthy lung tissue is light and spongy, and easily inflated, diseased lung tissue may be heavy and waterlogged and difficult to inflate, and therefore may collapse, allowing blood to pass through it without exchanging any gases (this is known as shunt). Simply applying higher pressures may not be the answer: this may just overdistend adjacent areas of healthier lung. The ventilator must therefore provide a series of breaths whose volume and pressure are very closely controlled. Every aspect of a mechanical breath may now be adjusted by the anaesthetist: the volume, the pressure, the frequency, and the ratio of inspiratory time to expiratory time are only the basic factors.”

“All anaesthetic drugs are poisons. Remember that in achieving a state of anaesthesia you intend to poison someone, but not kill them – so give as little as possible. [Introductory quote to a chapter, from an Anaesthetics textbook – US] […] Other cells besides neurons use action potentials as the basis of cellular signalling. For example, the synchronized contraction of heart muscle is performed using action potentials, and action potentials are transmitted from nerves to skeletal muscle at the neuromuscular junction to initiate movement. Local anaesthetic drugs are therefore toxic to the heart and brain. In the heart, local anaesthetic drugs interfere with normal contraction, eventually stopping the heart. In the brain, toxicity causes seizures and coma. To avoid toxicity, the total dose is carefully limited”.

Links of interest:

General anaesthesia.
Muscle relaxant.
Arthur Ernest Guedel.
Guedel’s classification.
Beta rhythm.
Frances Burney.
Henry Hill Hickman.
Horace Wells.
William Thomas Green Morton.
Diethyl ether.
James Young Simpson.
Joseph Thomas Clover.
Inhalational anaesthetic.
Pulmonary aspiration.
Principles of Total Intravenous Anaesthesia (TIVA).
Patient-controlled analgesia.
Airway management.
Oropharyngeal airway.
Tracheal intubation.
Laryngeal mask airway.
Anaesthetic machine.
Soda lime.
Sodium thiopental.
Neuromuscular-blocking drug.
Gate control theory of pain.
Multimodal analgesia.
Hartmann’s solution (…what this is called seems to be depending on whom you ask, but it’s called Hartmann’s solution in the book…).
Local anesthetic.
Karl Koller.
Regional anesthesia.
Spinal anaesthesia.
Epidural nerve block.
Intensive care medicine.
Bjørn Aage Ibsen.
Chronic pain.
Pain wind-up.
John Bonica.
Twilight sleep.
Veterinary anesthesia.
Pearse et al. (results of paper briefly discussed in the book).
Awareness under anaesthesia (skip the first page).
Pollard et al. (2007).
Postoperative nausea and vomiting.
Postoperative cognitive dysfunction.
Monk et al. (2008).
Malignant hyperthermia.
Suxamethonium apnoea.


February 13, 2017 - Posted by | books, Chemistry, medicine, papers, Pharmacology

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